Atherosclerosis is mainly a worsening problem related to advancing age with a chronic inflammatory involvement. It leads to the blockage of normal blood flow pathway and hence ischemia of the distal part of limb. The saliva of leech contains number of anti-thrombotic chemicals such as hirudin, bfrudin, haemadin and granulin-like. These chemicals inhibit thrombin fibrin binding and prevent formation of atheroma or plaque. Marham-e-raal is well known formulation for non-healing ulcers irrespective of their origin. It contains potent healing agents that are greatly beneficial for achieving the healing of ulcers.