This study provides further evidence to classify TAO as an autoimmune disease involving multiple hypersensitivities reaction. Mainly Type III hypersensitivity. However, Type IV and type II reactions are also involved. This study found IgE elevated in the sera of TAO patients, suggesting a Type I hypersensitivity reaction may be involved or plays some role in TAO autoimmunity. TAO vascular wall inflammation, blood hypercoagulation and thrombosis in the vascular lumen are considered a consequence of TAO autoimmune pathogenesis. This study not only elucidates the autoimmune pathogenesis of TAO. But also provides a new approach for clinical treatment.