Isolated left main coronary artery disease (ILMCAD) is not a frequent one. Though coronary artery bypass graft surgery (CABG) was thinks to be the standard treatment for left main coronary stenosis (LMCA). However, in the real world scenario, multiple studies suggest that treatment of patients with isolated left main coronary artery disease (ILMCAD) with percutaneous coronary intervention (PCI) can be a safe and suitable option.This prospective observational study was carried out for 1 year between ‘01st February 2021 to 31st January 2022’. A total of 10 patients presented with Angina or NSTEMI and whom CAG reveals isolated left main coronary artery diseases were enrolled for this study. PCI to Left Main Coronary Artery was done with newer generation DES for all of this patients and six months outcome was recorded.