The reported number of PLHIV ≥ 15 years of age receiving ART from USAID-supported facilities increased in 15 (94%) countries Conclusion: Proactive, coordinated service delivery and strategic supply chain adjustments protected high quality HIV treatment and increased uptake of DTG, resulting in millions of PLHIV receiving the benefits of DTG-based treatment during the first years of the COVID-19 pandemic. The introduction and scaling of DTG-based regimens as planned despite COVID-19 demonstrated the ability of PEPFAR and MoH to engage in proactive supply planning and monitoring, while ensuring job aids and training were available to educate providers. The successes and lessons learned will allow the global health community to respond more effectively to inevitable, future disruptions.