Tinospora cordifolia is used as an immunomodulator, to treat liver and other systemic diseases. Many people self-medicate with T.cordifolia to boost immunity in the COVID pandemic. However, the consummation of T.cordifolia in high doses and longer duration with or without the underlying liver disease can lead to hepatotoxicity. Variability in population may depend upon age, sex, doses, duration, liver status, and genetic makeup. Disease presentation is mild to moderate, and rare mortality can happen in patients with underlying liver disease. Further studies are required to understand Tinospora codifolia, induced DILI in detail.